Nature gave us growth factors.
We turn them into medicines.
Nature gave us growth factors.
We turn them into medicines.
Why IGF-1?
IGF-1 is the body’s most powerful growth factor, driving repair and regeneration in numerous tissues. Cavalry focuses this power, directing IGF-1 to specific tissues to create precise, well-tolerated treatments.
Simple as ABC:
Start with an antibody that binds to a specific tissue
Use protein engineering to remove one antigen binding arm
Fuse IGF-1 to the antibody to create an Antibody-Biologic Conjugate
CAV-011
An engineered variant of IGF-1 that avoids inhibition by IGF-1 binding proteins, driving regeneration of key corneal structures.
CAV-033
An ABC that directs IGF-1 to skeletal muscle. In preclinical studies, it dramatically increases muscle mass and strength.
CAV-044
An ABC that targets IGF-1 to Schwann cells to promote re-myelination. CAV-044 is a potential therapy for peripheral neuropathies.
Local action, where it matters.
When used as a drug, IGF-1 is short-lived, broadly distributed, and burdened by systemic side effects. Cavalry engineers IGF-1 for precision, driving repair only where it is needed. The result: Antibody-Biologic Conjugates (ABCs) that safely target regeneration of the eye, muscle, nervous system, and beyond.
Our medicines target diseases in these tissues
Eyes
Drives regeneration of multiple corneal cell layers to reverse disease.
Muscles
Targeted IGF-1 grows muscle, improves strength, and reduces fat.
Nerves
Schwann-cell-targeted IGF-1 slows or reverses peripheral neuropathies.
See our Pipeline
